Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The histocompatibility system in schizophrenia]

W F Gattaz, H Beckmann

    Arquivos De Neuro-Psiquiatria
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Association study of functional polymorphisms of dopaminergic pathway in epilepsy-related factors of temporal lobe epilepsy in Brazilian population.

    European journal of neurology·2018
    Same author

    State-dependent microstructural white matter changes in drug-naïve patients with first-episode psychosis.

    Psychological medicine·2017
    Same author

    Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.

    Molecular psychiatry·2017
    Same author

    5-hydroxytryptamine1A receptor density in the hippocampus of patients with temporal lobe epilepsy is associated with disease duration.

    European journal of neurology·2017
    Same author

    Efficacy and safety of BAY 81-8973, a full-length recombinant factor VIII: results from the LEOPOLD I trial.

    Haemophilia : the official journal of the World Federation of Hemophilia·2016
    Same author

    Corrigendum to cytochrome P450 genotypes are not associated with refractoriness to antipsychotic treatment [Schizophr. Res. 168 (2015) 587-588].

    Schizophrenia research·2016
    Same journal

    Prevalence and predictors of low bone mineral density in Myasthenia gravis.

    Arquivos de neuro-psiquiatria·2026
    Same journal

    Hypochondriasis, somatic amplification, and pain beliefs in patients with medication overuse headache.

    Arquivos de neuro-psiquiatria·2026
    Same journal

    Ozzy Osbourne and Parkinson's disease: from darkness to awareness.

    Arquivos de neuro-psiquiatria·2026
    Same journal

    The weight of genotype on the clinical presentation of COQ7-related hereditary motor axonal neuropathy: a case series and literature review.

    Arquivos de neuro-psiquiatria·2026
    Same journal

    Rituximab as a sustainable high-efficacy solution for multiple Sclerosis in Brazil.

    Arquivos de neuro-psiquiatria·2026
    Same journal

    Reply to: "Sleep quality is influenced by multiple factors and cannot be reduced to the volume of pineal gland calcification".

    Arquivos de neuro-psiquiatria·2026
    See all related articles

    Human leucocyte antigen (HLA) B27 is more common in schizophrenia patients, particularly those with paranoid or chronic forms. This suggests HLA typing may aid in schizophrenia

    Area of Science:

    • Immunogenetics
    • Psychiatric Genetics

    Context:

    • Human leucocyte antigens (HLA) are linked to autoimmune diseases and familial occurrences.
    • Previous studies on HLA and psychiatric disorders, including schizophrenia, yielded contradictory results.
    • This study investigated HLA specificities in German schizophrenic patients and controls.

    Purpose:

    • To investigate the phenotype frequencies of HLA specificities in schizophrenic patients.
    • To determine if specific HLA types correlate with schizophrenia subtypes, prognosis, or disease onset.
    • To explore the potential of HLA typing in schizophrenia research and clinical applications.

    Summary:

    • A significantly increased frequency of HLA-B27 was observed in schizophrenic patients overall, and in subgroups including paranoid, chronic, poor prognosis, and early-onset cases.

    Related Experiment Videos

  • Elevated HLA-A9 incidence was noted in chronic, poor prognosis, and early-onset schizophrenic subgroups.
  • The combined HLA-A9-B27 phenotype was found more frequently in patients (7%) than controls (0.63%), especially in chronic paranoid patients with poor prognosis.

    • Impact:

    • Findings suggest HLA-B27 and HLA-A9 may serve as markers for genetic heterogeneity in schizophrenia.
    • HLA typing could potentially assist in genetic studies, differential diagnosis, and prognosis of schizophrenia.
    • The associations, while significant, are below 100%, indicating that environmental factors also play a crucial role in schizophrenia etiology.