[Effect of rimazolium (Probon) on biotransformation reactions in the rat]

Rimazolium inhibits ethylmorphine-N-demethylation and ethoxycoumarin-O-deethylation by rat liver homogenate when added in vitro in dependence on reaction differently, but marked effects are observed with high concentrations only (10(-3) mol). Both reactions are inhibited after administration of a high sedative dose (180 mg/kg) by 30-40%, after a non-sedative dose no inhibition could be observed. After a 4 d treatment both reactions were not influenced when investigated 24 h after the last administration, the induction by phenobarbital is inhibited in case of ethylmorphine-N-demethylation by rimazolium, but increased in case of ethoxycoumarin-O-deethylation.