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Presumed blastomycosis endophthalmitis

W I Bond, C V Sanders, L Joffe

    Annals of Ophthalmology
    |December 1, 1982
    PubMed
    Summary
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    Disseminated North American blastomycosis can affect the eyes, causing inflammation and lesions. Early treatment with amphotericin B showed improvement, but the patient later succumbed to a secondary bacterial infection.

    Area of Science:

    • Mycology
    • Ophthalmology
    • Infectious Diseases

    Background:

    • North American blastomycosis is a fungal infection caused by Blastomyces dermatitidis.
    • Ocular involvement in blastomycosis is rare but can lead to significant vision impairment.

    Observation:

    • A 49-year-old outdoor laborer presented with endophthalmitis and posterior segment lesions in one eye, and skin lesions in another.
    • Skin biopsy confirmed disseminated North American blastomycosis.

    Findings:

    • Intravenous amphotericin B therapy led to slow improvement of ocular inflammation.
    • Ocular lesions were presumed to be caused by Blastomyces dermatitidis.

    Implications:

    • This case highlights the importance of considering fungal infections in the differential diagnosis of ocular inflammation, especially in endemic areas.

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  • Prompt diagnosis and treatment are crucial for managing blastomycosis, although secondary infections can pose a significant threat.