Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tuberculous manifestations in children

M B Raghu, Y S Patel, C Chintu

    Medical Journal of Zambia
    |June 1, 1980
    PubMed
    Summary

    Primary tuberculosis in Zambian children frequently co-occurs with protein energy malnutrition. Bacillus Calmette-Guérin (BCG) vaccination showed limited protection against tuberculosis in this pediatric population.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Strategies for nevirapine initiation in HIV-infected children taking pediatric fixed-dose combination "baby pills" in Zambia: a randomized controlled trial.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2010
    Same author

    The effect of transdermal nitroglycerine on intrathecal fentanyl with bupivacaine for postoperative analgesia following gynaecological surgery.

    Anaesthesia and intensive care·2010
    Same author

    Case-control study to identify factors associated with mortality among patients with methicillin-resistant Staphylococcus aureus bacteraemia.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2009
    Same author

    A review of the epidemiology of cancers at the University Teaching Hospital, Lusaka, Zambia.

    Tropical doctor·2009
    Same author

    Clinical profile of group A meningococcal outbreak in Delhi.

    Indian pediatrics·2009
    Same author

    Immunogenicity and safety of an indigenously developed DTPw hepatitis B combination vaccine in Indian infants.

    Indian pediatrics·2008

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Public Health

    Background:

    • Tuberculosis (TB) remains a significant global health challenge, particularly in resource-limited settings.
    • Pediatric tuberculosis presents unique diagnostic and management complexities.
    • Understanding the epidemiological and clinical features of primary TB in children is crucial for effective control strategies.

    Purpose of the Study:

    • To analyze the clinical characteristics and outcomes of primary tuberculosis in a cohort of Zambian children.
    • To investigate the association between protein energy malnutrition and primary tuberculosis in this population.
    • To evaluate the effectiveness of Bacillus Calmette-Guérin (BCG) vaccination in preventing childhood tuberculosis.

    Main Methods:

    • Retrospective analysis of 110 cases of primary tuberculosis in children from Zambia.
    • Assessment of nutritional status, focusing on protein energy malnutrition.
    • Documentation of pulmonary and extra-pulmonary manifestations.
    • Evaluation of BCG vaccination history and its correlation with disease incidence.

    Main Results:

    • Nearly half (47%) of the children with primary tuberculosis presented with protein energy malnutrition.
    • Simple primary tuberculosis was the most common pulmonary manifestation, followed by segmental lesions.
    • A significant proportion of cases exhibited extra-pulmonary involvement, predominantly tuberculous lymphadenitis.
    • Bacillus Calmette-Guérin (BCG) inoculation did not confer protection in 33.6% of the children studied.

    Conclusions:

    • Protein energy malnutrition is highly prevalent among Zambian children with primary tuberculosis, highlighting the need for integrated nutritional and TB management.
    • Primary tuberculosis in children manifests with diverse pulmonary and extra-pulmonary patterns, requiring comprehensive diagnostic approaches.
    • The observed limited efficacy of BCG vaccination underscores the ongoing challenge of TB prevention in high-burden settings and the need for alternative strategies.

    Related Experiment Videos