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[Antibodies against human lymphocytes]

H Koshiba, K Kasai, T Uede

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|December 1, 1982

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Hybridoma technology enables the identification and characterization of human lymphoid cell surface antigens using monoclonal antibodies. This review compares these antibodies, highlighting their similarities and differences for clinical applications.

Area of Science:

Immunology
Cell Biology

Context:

Hybridoma technology has revolutionized the study of human lymphoid cells.
Significant advancements have been made in generating monoclonal antibodies (mAbs) against these cells.

Purpose:

To review and compare monoclonal antibodies targeting human lymphoid cell surface antigens.
To elucidate the similarities and differences among these critical diagnostic and therapeutic tools.

Summary:

Monoclonal antibodies generated via hybridoma technology are key for identifying and characterizing cell surface antigens on human lymphoid cells.
These antibodies have demonstrated significant potential in clinical medicine.
This review consolidates current knowledge on these mAbs, detailing their comparative features.

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Impact:

Facilitates a deeper understanding of lymphoid cell populations.
Aids in the development of targeted therapies and diagnostic strategies.
Provides a comprehensive resource for researchers and clinicians in hematology and immunology.