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A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
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A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

Inhibition of the immune response by Fc receptor-bound specific antibody on T lymphocytes

T M Setcavage, Y B Kim

    Journal of Immunology (Baltimore, Md. : 1950)
    |February 1, 1980
    PubMed

    Removal of naturally occurring membrane-bound antibody from the surface of nonadherent spleen cells by pronase enhances the in vitro plaque-forming cell response to sheep erythrocytes, and this enhancement can be abrogated by preincubation of the enzyme-treated cells in anti-sheep red blood cell antibody. This inhibitory effect is specific in that prior absorption with sheep erythrocytes but not with noncross-reacting red blood cells removes the activity from antibody-containing preparations. Whole IgG molecules are necessary to bind to Fc receptor; F(ab')2 fragments do not inhibit. The functionally significant Fc receptor-bound antibody in this system is found on the T lymphocyte.

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