Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperlipoproteinemia in renal insufficiency

C C Heuck, E Ritz

    Nephron
    |January 1, 1980
    PubMed
    Summary

    Hyperlipoproteinemia is common in uremic patients, but its role in atherosclerosis is debated. Treatment involves diet or medication, though therapeutic guidelines are uncertain due to unclear pathogenic links.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    International collaborative assessment study of the AHD575 method for the measurement of blood haemoglobin.

    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit·2007
    Same author

    WHO's strategy on standardization in laboratory pathology.

    Rinsho byori. The Japanese journal of clinical pathology·1997
    Same author

    The role of WHO and international organizations in promoting international standardization.

    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies·1995
    Same author

    The World Health Organization's role and future plans in laboratory standardization.

    Scandinavian journal of clinical and laboratory investigation. Supplementum·1993
    Same author

    De novo glomerulonephritis in patients during remission from Wegener's granulomatosis.

    Clinical nephrology·1992
    Same author

    Reduced capillary density in the myocardium of uremic rats--a stereological study.

    Kidney international·1992

    Area of Science:

    • Nephrology
    • Cardiovascular Medicine
    • Metabolic Disorders

    Background:

    • Hyperlipoproteinemia frequently occurs in patients with uremia.
    • The contribution of hyperlipoproteinemia to atherogenesis in uremic individuals is not well understood.

    Purpose of the Study:

    • To investigate the role of hyperlipoproteinemia in atherogenesis among uremic patients.
    • To explore the underlying mechanisms of hyperlipoproteinemia in uremia, including lipoprotein catabolism and synthesis.

    Main Methods:

    • Analysis of lipoprotein metabolism in uremic patients.
    • Assessment of hepatic synthesis and catabolism of lipoproteins.
    • Evaluation of postheparin lipolytic activity and hepatic triglyceride lipase levels.

    Main Results:

    • The primary abnormality observed is reduced lipoprotein catabolism, with unchanged or low hepatic synthesis.
    • Hyperlipoproteinemia in uremia is often type IV and responsive to dietary changes (reduced carbohydrates, increased P/S ratio) or pharmacotherapy.

    Conclusions:

    • The pathogenic role of hyperlipoproteinemia in uremic atherogenesis requires further clarification.
    • Therapeutic strategies for hyperlipoproteinemia in uremia are debated due to uncertainties in its etiological significance.

    Related Experiment Videos