Hydramnios with hydrops fetalis and disseminated fetal neuroblastoma

A white primigravida with acute toxemia and hydramnios delivered a hydropic male infant who died. A neuroblastoma of the right adrenal gland was found with metastic spread to the liver and other organs. The placental capillaries contained tumor cells. Pathogenesis of hydrops, hydramnios, and maternal toxemia and the consequence of tumor cells in the placenta are discussed.