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[Systemic candidiasis in the newborn. Report of 3 cases]
Boletin Medico Del Hospital Infantil De Mexico
|January 1, 1980
Summary
Three infants with systemic candidiasis experienced spontaneous recovery, presenting a clinical picture similar to fatal cases. Predisposing factors included antibiotic use, catheters, and immune deficiency, highlighting diagnostic challenges in infant fungal infections.
Area of Science:
- Pediatrics
- Mycology
- Infectious Diseases
Background:
- Systemic candidiasis in infants poses diagnostic and therapeutic challenges.
- Clinical presentation can mimic bacterial sepsis, complicating early identification.
- Spontaneous recovery from systemic fungal infections is rare but documented.
Observation:
- Describes 3 infants with systemic candidiasis who achieved spontaneous resolution.
- Compares clinical and laboratory findings to 16 fatal cases, some with bacterial sepsis.
- Identifies predisposing factors: prolonged antibiotic therapy, indwelling catheters, and immunoglobulin A (IGA) deficiency.
Findings:
- Diagnosis suspected due to prolonged illness, non-specific symptoms, poor antibiotic response, and negative bacterial cultures.
- Confirmed by Candida presence in multiple sites and positive serological tests.
- Clinical similarity between spontaneously resolving and fatal cases noted.
Implications:
- Highlights the importance of considering fungal infections in critically ill infants, even with negative bacterial cultures.
- Suggests potential for spontaneous resolution in select cases of infant systemic candidiasis.
- Underscores the need for further research into diagnostic markers and therapeutic strategies for pediatric mycoses.