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[Systemic candidiasis in the newborn. Report of 3 cases]

J Larracilla Alegre, M H Echavarría Loya, A Martínez Sánchez

    Boletin Medico Del Hospital Infantil De Mexico
    |January 1, 1980
    PubMed

    Insights

    Three infants with systemic candidiasis experienced spontaneous recovery, presenting a clinical picture similar to fatal cases. Predisposing factors included antibiotic use, catheters, and immune deficiency, highlighting diagnostic challenges in infant fungal infections.

    Area of Science:

    • Pediatrics
    • Mycology
    • Infectious Diseases

    Background:

    • Systemic candidiasis in infants poses diagnostic and therapeutic challenges.
    • Clinical presentation can mimic bacterial sepsis, complicating early identification.
    • Spontaneous recovery from systemic fungal infections is rare but documented.

    Observation:

    • Describes 3 infants with systemic candidiasis who achieved spontaneous resolution.
    • Compares clinical and laboratory findings to 16 fatal cases, some with bacterial sepsis.
    • Identifies predisposing factors: prolonged antibiotic therapy, indwelling catheters, and immunoglobulin A (IGA) deficiency.

    Findings:

    • Diagnosis suspected due to prolonged illness, non-specific symptoms, poor antibiotic response, and negative bacterial cultures.
    • Confirmed by Candida presence in multiple sites and positive serological tests.
    • Clinical similarity between spontaneously resolving and fatal cases noted.

    Implications:

    • Highlights the importance of considering fungal infections in critically ill infants, even with negative bacterial cultures.
    • Suggests potential for spontaneous resolution in select cases of infant systemic candidiasis.
    • Underscores the need for further research into diagnostic markers and therapeutic strategies for pediatric mycoses.

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