The effect of indomethacin on isoprenaline-induced renin secretion in the cat

In vivo isoprenaline infusion (0.1 micrograms/kg.min)) into the renal artery of unilaterally nephrectomized cats elicited a 5-fold increase in plasma renin concentration (PRC). This increase was suppressed by concomitant administration of propranolol (0.3 mg/kg.min). Indomethacin (250 micrograms/kg.min) intrarenally infused prior to the administration of isoprenaline, abolished the isoprenaline-induced increase in PRC. It is suggested that prostaglandins mediate beta-adrenergic-activated renin release.