Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Codon catalog usage and the genome hypothesis

R Grantham, C Gautier, M Gouy

    Nucleic Acids Research
    |January 11, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Altrenogest treatment reduces the stress response of three-year-old warmblood mares during their initial equestrian training.

    Domestic animal endocrinology·2022
    Same author

    [A definition of work-related asthma and its social and occupational consequences in adults and teenagers].

    Revue des maladies respiratoires·2021
    Same author

    Effects of blue monochromatic light directed at one eye of pregnant horse mares on gestation, parturition and foal maturity.

    Domestic animal endocrinology·2021
    Same author

    DRESS with eslicarbazepine: The value of allergological exploration.

    Annales de dermatologie et de venereologie·2021
    Same author

    The evaluation of intracranial bypass patency in neurosurgical practice.

    Neuro-Chirurgie·2020
    Same author

    Transient suppression of ovulatory ovarian function in pony mares after treatment with slow-release deslorelin implants.

    Domestic animal endocrinology·2020
    Same journal

    Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

    Nucleic acids research·2026
    Same journal

    Correction to 'Differentiable partition function calculation for RNA'.

    Nucleic acids research·2026
    Same journal

    Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

    Nucleic acids research·2026
    Same journal

    Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

    Nucleic acids research·2026
    Same journal

    Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

    Nucleic acids research·2026
    Same journal

    Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

    Nucleic acids research·2026
    See all related articles

    Each genome exhibits a unique codon usage system, influencing mRNA sequences. This study introduces a new genetic distance metric based on these systematic third-base codon choices.

    Area of Science:

    • Molecular Biology
    • Genomics
    • Bioinformatics

    Background:

    • Codon usage varies across organisms and genes.
    • Understanding these variations is crucial for deciphering genetic code and evolution.

    Purpose of the Study:

    • To analyze codon frequencies across diverse genomes and genes.
    • To identify patterns in codon selection and their relation to genome type.
    • To propose a new metric for genetic distance based on codon usage.

    Main Methods:

    • Systematic analysis of published mRNA sequences (≥50 codons).
    • Categorization of codon frequencies by genome type and individual gene.
    • Comparison of codon choice strategies between normal and frameshift genes.

    Related Experiment Videos

    Main Results:

    • Identified a consistent codon usage system within similar genomes.
    • Observed significant differences in codon choice strategies between normal and frameshift genes.
    • Demonstrated that third-base codon choices are key differentiators in mRNA sequences.

    Conclusions:

    • Each genome possesses a distinct codon selection system, supporting the 'genome hypothesis'.
    • Codon usage patterns can define a novel genetic distance, reflecting coding strategies.
    • The genome, rather than individual genes, appears to be the primary unit of selection.