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Related Experiment Videos

Depression masquerading as diabetic neuropathy

R W Turkington

    JAMA
    |March 21, 1980
    PubMed
    Summary

    This study found that painful diabetic neuropathy in lower extremities is often a form of depression. Antidepressant drugs like imipramine and amitriptyline effectively treated both the pain and depression in patients.

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    Area of Science:

    • Neurology
    • Psychiatry
    • Pharmacology

    Background:

    • Diabetic neuropathy is a common complication of diabetes.
    • Painful diabetic neuropathy significantly impacts patients' quality of life.
    • Depression is frequently comorbid with chronic pain conditions.

    Purpose of the Study:

    • To evaluate depression in patients with painful diabetic neuropathy.
    • To assess the efficacy of antidepressant drug therapy for this condition.

    Main Methods:

    • A double-blind controlled study was conducted.
    • Fifty-nine patients with painful diabetic neuropathy were included.
    • Psychiatric interviews and Kupfer-Detre test scores were used for depression assessment.
    • Treatment involved imipramine hydrochloride or amitriptyline hydrochloride.

    Main Results:

    • All patients exhibited substantial depression.
    • Treatment with imipramine or amitriptyline led to complete remission of lower extremity pain within 10 weeks.
    • Concomitant relief of depression symptoms and normalization of depression test scores were observed.

    Conclusions:

    • Painful diabetic neuropathy of the lower extremities may represent a depressive equivalent in many cases.
    • Imipramine and amitriptyline are effective treatments for painful diabetic neuropathy associated with depression.

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