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Related Experiment Videos

Liver damage from long-term methyltestosterone

D Westaby, S J Ogle, F J Paradinas

    Lancet (London, England)
    |August 6, 1977
    PubMed
    Summary

    Long-term methyltestosterone therapy in patients can lead to abnormal liver function and scans. This androgen use is linked to liver damage, including peliosis hepatis and tumors.

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    Area of Science:

    • Hepatology
    • Endocrinology
    • Pharmacology

    Background:

    • Methyltestosterone is a synthetic androgen used in hormone replacement therapy.
    • Long-term androgen use has been associated with potential adverse effects on the liver.

    Purpose of the Study:

    • To investigate the liver-related side effects of long-term methyltestosterone therapy.
    • To identify specific androgen types linked to liver abnormalities.

    Main Methods:

    • Retrospective analysis of 60 patients (42 female transsexuals, 18 impotent males) on long-term methyltestosterone.
    • Assessment of liver function tests, liver scans, and liver biopsies.
    • Correlation of findings with duration of therapy and androgen type.

    Main Results:

    • 19 of 60 patients exhibited abnormal liver function tests.
    • 33 of 52 patients showed abnormal liver scans, especially those treated >1 year.
    • Liver biopsies revealed hepatocyte accumulation, centrilobular vein changes, and early peliosis hepatis; one patient developed hepatic adenoma.

    Conclusions:

    • Long-term methyltestosterone therapy is associated with significant liver abnormalities.
    • 17alpha-alkylated steroids, including methyltestosterone, are implicated in cholestatic jaundice, peliosis hepatis, and liver tumors.

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