Chronic copper poisoning in sheep. A review of the literature

A review is given of chronic copper poisoning in sheep. The sensitivity of sheep to excess of copper is described and compared to that of other ruminant species. Possible reasons for the accumulation of copper in the liver are mentioned. The absorption, distribution and excretion of copper in sheep are briefly described. Possible modes of action of copper on target cells are reviewed. The interaction of copper with the most important interfering substances is described. An account is given of the features of the disease, clinical findings, clinical pathology and necropsy findings. Possible methods of treatment and control are discussed.