[Dynamics of insulin secretion in response to a peroral glucose load and its diagnostic significance]

The changes in the immunoreactive insulin (IRI) content in the blood plasma were studied during oral glucose tolerance test (GTT) in 96 women. The IRI rise was biphasic in persons with a normal type of GTT with the maximum after glucose administration in 10 and 30 minutes in persons of normal weight and in 10 and 60 minutes in obese ones. When patients with diabetic type of GTT of normal and excessive weight, and persons with prediabetes and healthy volunteers were examined after a 36-hour fasting, elevation of the IRI level was later, monophasic, with the maximum at the 90th-120th minute after glucose administration. The mechanisms of disturbances in the early insulin response to glucose and diagnostic significance of the tests under study are discussed.