[Comparative activity of depot sulfanilamides in experimental infection in mice caused by K1. pneumoniae]

The chemotherapeutic activity of 6 sulfanilamide depots, i.e. sulfalene, sulfamonomethoxin, sulfadimethoxin, bayrena, pallidin and sulfapyridazin was studied on 890 albino mice inoculated intranasally or intraperitoneally with 51. pneumoniae, strain 444. Sulfadimesin and domian, 2 sulfanilamides of short action served as the control. The drugs were administered orally in a dose of 500 mg/kg daily for 5 days. High efficacy of the sulfanilamide depots in the treatment of the 51. pneumoniae infected mice and low activity of the short-action drugs were shown, which was confirmed by the data of the pathomorphological investigation in experimental pneumonia. Sulfalene and sulfamonomethoxin proved to be the most active. Differences in the activity of the sulfanilamide depots depending on the experimental model were found. It is recommended that the combined effect of sulfanilamide depots and antibiotics be studied on infections caused by 51. pneumoniae.