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Mitral valve prolapse--a review

P J Engel, J R Hickman

    Aviation, Space, and Environmental Medicine
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Systolic click-murmur syndrome, or mitral valve prolapse (MVP), involves abnormal mitral leaflet movement. While often benign, it can mimic other heart conditions and rarely carries risks like arrhythmias.

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    Area of Science:

    • Cardiology
    • Valvular Heart Disease
    • Genetics

    Background:

    • The systolic click-murmur syndrome, now understood as mitral valve prolapse (MVP), has regained research interest.
    • Previously considered benign and extracardiac, MVP is now recognized as abnormal systolic herniation of mitral leaflets into the left atrium.

    Purpose of the Study:

    • To review the current understanding of mitral valve prolapse (MVP).
    • To highlight the diverse clinical presentations and potential risks associated with MVP.

    Main Methods:

    • Literature review of recent studies on systolic click-murmur syndrome/MVP.
    • Analysis of clinical manifestations and diagnostic approaches for MVP.

    Main Results:

    • MVP is a common, often benign, hereditary disorder with varied etiologies, sometimes resembling coronary artery disease.

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  • A small subset of patients with MVP faces risks of malignant arrhythmias and sudden death, requiring further characterization.

    • Conclusions:

    • Noninvasive methods are typically sufficient for MVP diagnosis, but left ventricular cineangiography remains definitive.
    • Future research should correlate MVP severity, clinical features, and prognosis in both symptomatic and asymptomatic individuals.