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Related Experiment Videos

Infections in leukemic children: a prospective analysis

H V Kosmidis, J M Lusher, T C Shope

    The Journal of Pediatrics
    |May 1, 1980
    PubMed
    Summary

    Infections frequently cause fever in leukemic children, especially during active disease. Bacterial infections are serious, particularly with low granulocyte counts, while viral infections are common during remission.

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    Area of Science:

    • Pediatric Oncology
    • Infectious Diseases
    • Hematology

    Background:

    • Febrile episodes are common in children with leukemia.
    • Understanding infection types and incidence is crucial for managing febrile episodes in pediatric leukemia patients.

    Purpose of the Study:

    • To determine the incidence and types of infections associated with febrile episodes in leukemic children.
    • To analyze the relationship between leukemic activity and infection occurrence.
    • To identify risk factors for serious infections and mortality.

    Main Methods:

    • A prospective study conducted over 28 months.
    • Involved 54 children diagnosed with leukemia.
    • Monitored febrile episodes and documented infections.

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    Main Results:

    • Infections caused 71% of 199 febrile episodes.
    • Two-thirds of febrile episodes and 57% of infections occurred during active leukemia.
    • Serious bacterial infections were linked to absolute granulocyte counts < 500/mm3; septicemia caused 7 of 17 deaths.
    • Pseudomonas infections followed colonization; viral infections (CMV, VZV, EBV) were more common during remission.

    Conclusions:

    • Infections are a major cause of fever in pediatric leukemia.
    • Leukemic activity influences infection risk.
    • Close monitoring and management of infections, particularly bacterial ones, are critical for improving outcomes in leukemic children.