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Deafferentation and causalgia

R R Tasker, L W Organ, P Hawrylyshyn

    Research Publications - Association for Research in Nervous and Mental Disease
    |January 1, 1980
    PubMed
    Summary
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    Deafferentation pain, distinct from somatic pain, arises from central nervous system changes. These persistent changes, even after stimulus removal, can cause chronic pain through neural hypersensitivity.

    Area of Science:

    • Neuroscience
    • Pain Medicine
    • Neurology

    Background:

    • Deafferentation pain is a distinct clinical entity separate from somatic pain.
    • It can occur in both cancerous and nonmalignant conditions.
    • This pain is characterized by unique clinical features and responses to interventions.

    Purpose of the Study:

    • To review the concept of deafferentation pain.
    • To present evidence for its underlying mechanisms.
    • To explore the role of the central nervous system in its persistence.

    Main Methods:

    • Review of clinical features and therapeutic responses.
    • Analysis of evidence for central nervous system alterations.
    • Examination of the mesencephalic tegmentum's role.

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    Main Results:

    • Deafferentation pain results from progressive central nervous system changes.
    • These alterations persist even after the initial stimulus is removed.
    • The mesencephalic tegmentum may be involved in a denervation hypersensitivity pathway.

    Conclusions:

    • Deafferentation pain involves persistent central nervous system alterations.
    • Denervation hypersensitivity in the reticulothalamocortical system may underlie this pain.
    • Stimulation of this system can evoke pain, similar to memory recall from cortical stimulation.