Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-specific immunity in nephrotic syndrome

S Yetgin, A Gur, U Saatci

    Acta Paediatrica Scandinavica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of the therapeutic efficacy of topical tranexamic acid, epinephrine, and lidocaine in stopping bleeding in non-traumatic epistaxis: a prospective, randomized, double-blind study.

    European review for medical and pharmacological sciences·2022
    Same author

    Social involvement, socio-economic status and subjective well-being of parents of offspring with intellectual and developmental disabilities.

    Journal of intellectual disability research : JIDR·2021
    Same author

    Limitations of cadaveric organ donation on judicial cases and problems confronted in autopsy: Istanbul data in comparative perspective.

    Forensic science international·2014
    Same author

    Can the patient-reported outcome instruments determine disease activity in rheumatoid arthritis?

    Bratislavske lekarske listy·2011
    Same author

    School environment and sanitation in rural India.

    Journal of global infectious diseases·2010
    Same author

    Has specialization isolated practitioners?

    Indian journal of dental research : official publication of Indian Society for Dental Research·2010

    Patients with nephrotic syndrome exhibit impaired bacterial killing by polymorphonuclear neutrophils (PMN). This defect, along with reduced serum opsonic activity, contributes to increased infection susceptibility in these individuals.

    Area of Science:

    • Immunology
    • Nephrology
    • Infectious Diseases

    Background:

    • Nephrotic syndrome is associated with increased susceptibility to bacterial infections.
    • The underlying mechanisms, particularly immune function, require further elucidation.

    Purpose of the Study:

    • To investigate the bactericidal capacity of polymorphonuclear neutrophils (PMN) and serum opsonic activity in patients with nephrotic syndrome.
    • To determine the relationship between these immune functions and clinical parameters.

    Main Methods:

    • Comparative study involving 29 patients with nephrotic syndrome and 29 healthy controls.
    • Assessed bactericidal capacity against Staphylococcus aureus and Escherichia coli.
    • Measured serum opsonic activity.

    Related Experiment Videos

    Main Results:

    • Patients with nephrotic syndrome showed significantly impaired PMN bactericidal capacity for both bacteria compared to controls.
    • Serum opsonic activity was reduced in up to 50% of patients but did not reach statistical significance.
    • No correlation was found between impaired bactericidal capacity and serum protein levels, lipids, age, or illness duration.

    Conclusions:

    • Bactericidal capacity of PMN is significantly impaired in nephrotic syndrome.
    • Serum opsonic activity may also be affected, contributing to infection risk.
    • Immune dysfunction in nephrotic syndrome appears reversible, as evidenced by normalized function in patients in remission.