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Protein AA and lattice corneal dystrophy

B J Mondino, C V Raj, M Skinner

American Journal of Ophthalmology

|March 1, 1980

Summary

This study identifies novel proteins, protein AA and protein AP, within the amyloid deposits of lattice corneal dystrophy. These findings advance our understanding of corneal amyloidosis and its molecular basis.

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Area of Science:

Ophthalmology
Histopathology
Biochemistry

Background:

Lattice dystrophy is an inherited corneal disease characterized by amyloid deposition.
Corneal transplantation is a common treatment for advanced lattice dystrophy.

Observation:

A 73-year-old woman with lattice dystrophy underwent corneal transplantation.
Histopathology revealed eosinophilic deposits in the excised cornea, positive for Congo red and exhibiting green birefringence.

Findings:

Immunofluorescence identified the presence of protein AA and protein AP within the stromal amyloid deposits.
This is the first documented instance of protein AA and protein AP in lattice corneal dystrophy amyloid deposits.

Implications:

These findings contribute to the understanding of the molecular composition of corneal amyloid.
Identifying specific proteins involved may open avenues for targeted therapies for lattice corneal dystrophy.

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