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Lymphocyte function in relapsed pulmonary blastomycosis

P G Sohnle, B Varkey, H D Rose

    The Journal of Allergy and Clinical Immunology
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Two patients with recurrent pulmonary blastomycosis showed normal immune responses to common antigens and the fungus itself. This suggests their relapses are not due to a lack of lymphocyte responsiveness to Blastomyces dermatitidis.

    Area of Science:

    • Mycology
    • Immunology
    • Infectious Diseases

    Background:

    • Pulmonary blastomycosis is a fungal infection that can relapse even after antifungal treatment.
    • Investigating the immune system's role is crucial for understanding treatment failures.

    Observation:

    • Two patients experienced multiple relapses of pulmonary blastomycosis despite antifungal therapy.
    • Their immune cells (lymphocytes) responded normally to general skin tests and common microbial antigens.

    Findings:

    • Lymphocytes from both patients showed a positive response to Blastomyces dermatitidis antigens in lab tests.
    • Both lymphocyte transformation and lymphokine production were normal when exposed to the specific fungal antigens.

    Implications:

    Related Experiment Videos

    • The patients' relapses are unlikely due to a general inability of their lymphocytes to recognize or respond to Blastomyces dermatitidis.
    • Further research is needed to identify potential immunologic defects contributing to recurrent blastomycosis.