[Sensitivity of various metabolic processes to adrenaline and insulin experimental thyrotoxicosis]

The fasting hypoglycemia and hyperlipocidemia were observed in rabbits fed with massive doses of thyroidine. The hypoglycemic effect of insulin was diminished but its hypolipocidemic action rose. In the isolated diaphragm of rats given massive doses of 1-thyroxine insulin produced a more pronounced effect on glucose uptake than in the muscle of control animals. The hyperglycemic action of epinephrine in thyrotoxic rabbits remained unaltered, but its hyperlipocidemic effect proved to be less than in control animals. The in vitro effect of epinephrine on the adipose tissue lipolytic activity of severe thyrotoxic rats was less than that in control rats.