Related Experiment Video
Updated: Aug 12, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Activation of the renal pressure system following severe hypotension and its pathophysiologic significance
Abstract:
The renin activity of the juxtaglomerular apparatus following a period of 210 min of hemorrhagic hypotension was correlated with the blood volume retransfused in order to maintain a hypotensive blood pressure of 30 mm Hg. In an additional experiment the renin activity of the juxtaglomerular apparatus was measured in acute renal failure due to renal artery occlusion over 60 min. The increased renin activity after hemorrhagic hypotension indicates that the renin-angiotensin system contributes to pressure stabilization. The similar rise of the juxtaglomerular renin activity in hypotension as well as in renal artery occlusion suggests the active role of the renin-angiotensin system in acute renal failure following severe hemorrhagic hypotension.
Related Concept Videos
Hormonal Regulation
Hypertension and Regulation of Blood Pressure
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Hypertension II: Pathophysiology
Acute Kidney Injury II: Pathophysiology

