Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral dopamine receptors

B J Clark, K Menninger

    Circulation Research
    |June 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Dopamine causes blood vessel dilation, primarily in the kidneys and intestines. Research confirms specific dopamine receptors in blood vessels, suggesting their role in regulating blood pressure and flow.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Unsupervised Phenotyping Reveals Disrupted Neural Firing Characteristics in the Anterior Thalamus and Surrounding Brain Regions Following Third-Trimester Equivalent Alcohol Exposure in Mice.

    bioRxiv : the preprint server for biology·2025
    Same author

    An Integrated Platform for in vivo Electrophysiology in Spatial Cognition Experiments.

    bioRxiv : the preprint server for biology·2023
    Same author

    Cue polarization and representation in mouse home base behaviors.

    Animal cognition·2022
    Same author

    Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?

    Andrology·2018
    Same author

    In vitro aerodynamic characterization of the dose emitted during nebulization of tobramycin high strength solution by novel and jet nebulizer delivery systems.

    Pulmonary pharmacology & therapeutics·2016
    Same author

    A psychiatric fable.

    Bulletin of the Menninger Clinic·2014
    Same journal

    SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

    Circulation research·2026
    Same journal

    Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart.

    Circulation research·2026
    Same journal

    Targeting Late Na<sup>+</sup> Current: Too Late or Better Late Than Never?

    Circulation research·2026
    Same journal

    HFpEF-Any: Human Single-Nuclear Transcriptomics Challenging the Translational Validity of Current HFpEF Models.

    Circulation research·2026
    Same journal

    Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

    Circulation research·2026
    Same journal

    Meet the First Authors.

    Circulation research·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Neuroscience

    Background:

    • Dopamine is known to influence vascular tone, particularly in the renal and mesenteric circulations.
    • The precise mechanisms and receptor subtypes involved in dopamine-mediated vasodilation require further elucidation.
    • Growing evidence suggests the presence and function of vascular dopamine receptors.

    Purpose of the Study:

    • To investigate the specific dopamine receptors mediating vasodilation in the canine mesenteric vascular bed.
    • To explore the role of innervated vascular dopamine receptors in regulating blood flow.
    • To understand the contribution of dopamine receptors in sympathetic ganglia and nerve terminals to the overall cardiovascular effects of dopamine agonists.

    Main Methods:

    • In vitro studies using a perfused canine mesenteric vessel preparation.

    Related Experiment Videos

  • Pharmacological characterization of dopamine receptors using selective antagonists like methylergometrine and sulpiride.
  • Investigation of periarterial nerve stimulation in anesthetized dogs to assess neurogenic blood flow changes.
  • Analysis of cardiovascular responses to dopamine receptor agonists such as bromocriptine.

    • Main Results:

    • Dopamine-induced reductions in vascular resistance were selectively inhibited by methylergometrine and sulpiride, confirming specific receptor involvement.
    • Periarterial nerve stimulation increased superior mesenteric artery blood flow, an effect inhibited by haloperidol but not atropine or propranolol, indicating innervated dopamine receptors.
    • Dopamine receptors were identified at sympathetic ganglia and nerve terminals, contributing to the depressor effects of agonists by inhibiting noradrenaline release.
    • Bromocriptine and other dopamine agonists reduced blood pressure and heart rate, with variable effects on myocardial contractility, suggesting selective prejunctional receptor distribution.

    Conclusions:

    • Vascular dopamine receptors, particularly in the renal and mesenteric beds, mediate vasodilation.
    • Innervated dopamine receptors play a significant role in regulating vascular tone and blood flow.
    • Dopamine receptors in the sympathetic nervous system contribute to the systemic cardiovascular effects of dopamine agonists.