[Effect of ATP on the contractile activity of different sections of the digestive tract]

In chronic tests on fistulized dogs ATP only with its intravenous administration, starting from a dose of 0.33 mg/kg inhibited motility of the stomach, small and large intestines. The intensity and duration of the inhibitory effect depended on the dose of ATP administered, but beginning from the dose of 0.09 mg/kg the effect of saturation started developing. The adrenoblocking agents phentolamine and inderal, the sympatholytics isobarin and ornidum did not eliminate the inhibitory action of ATP. The latter effectively suppressed the periodic and food motility of the gastrointestinal tract, as well as the motility induced by the insulin-produced hypoglycemia, by carbacholine and methoclopramide.