Blood pressure response to a single daily dose of a clonidine-chlorthalidone combination

A single evening dose of a clonidine-chlorthalidone combination (Combipres) was compared with the usual twice-daily schedule in 11 patients with essential hypertension. No significant difference was found between the blood pressures recorded on the two regimens or between morning and afternoon pressures on the once-daily schedule. Only one patient did not maintain adequate blood pressure control. We suggest that some patients with essential hypertension can be adequately treated with a single daily dose of a combination of clonidine and chlorthalidone.