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Curing of Escherichia coli K12 plasmids by coumermycin
Molecular & General Genetics : MGG
|April 1, 1980
Abstract:
Low concentrations of the antibiotic coumermycin A1, the inhibitor of bacterial DNA gyrase, effectively eliminate pBR322, pMB9 and other ColE 1 related plasmids from E. coli K12 strains. The curing action of antibiotic seems to result from the plasmid degradation and not just from the inhibition of replication.