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Mutagens produced by Alternaria alternata

P M Scott, D R Stoltz

    Mutation Research
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Alternariol methyl ether, a metabolite from Alternaria alternata, showed weak mutagenicity in Salmonella typhimurium strain TA98. Further analysis of the fungus

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    Area of Science:

    • Mycology and Toxicology
    • Microbial Metabolism and Mutagenesis

    Background:

    • Alternaria alternata produces various secondary metabolites.
    • Some Alternaria metabolites may pose health risks due to potential toxicity.

    Purpose of the Study:

    • To assess the mutagenicity of specific Alternaria alternata metabolites.
    • To identify mutagenic compounds within A. alternata mycelium extracts.

    Main Methods:

    • Testing of alternariol, alternariol methyl ether, and tenuazonic acid for mutagenicity using Salmonella typhimurium strains TA98 and TA100.
    • Chromatographic separation of A. alternata mycelium extract.
    • Spectroscopic characterization of isolated compounds.

    Main Results:

    • Alternariol methyl ether exhibited weak mutagenicity in Salmonella typhimurium strain TA98 without metabolic activation.

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  • Mutagenic fractions were isolated from A. alternata mycelium extract.
  • A purified yellow pigment (C20H14O6) was identified within a mutagenic fraction.

    • Conclusions:

    • Alternariol methyl ether is a weakly mutagenic compound produced by Alternaria alternata.
    • Further investigation is warranted to fully characterize the mutagenic potential of A. alternata metabolites and their toxicological significance.