Periodic lateralized epileptiform complexes (PLEDs) in Creutzfeldt-Jakob disease

The electroencephalogram (EEG) of three patients with typical Creutzfeldt-Jakob disease (CJD) was characterized by periodic lateralized epileptiform complexes (PLEDs), which persisted and became bilateral. This unusual pattern preceded the characteristic EEG change of CJD. Persistence of PLEDs should suggest the diagnosis of CJD.