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Related Experiment Videos

Fixed eruption and fever after urography

A E Good, E Novak, L P Sonda

    Southern Medical Journal
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This case report details a patient experiencing recurrent fixed bullous eruptions and fever following intravenous urography contrast media. Delayed onset of symptoms complicated diagnosis, highlighting a rare adverse reaction to these diagnostic agents.

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    Area of Science:

    • Dermatology
    • Radiology
    • Pharmacology

    Background:

    • Intravenous urography utilizes contrast media for diagnostic imaging.
    • Adverse drug reactions to contrast media can manifest in various ways.
    • Ioderma, or skin reactions to iodinated contrast agents, is a recognized but uncommon phenomenon.

    Observation:

    • A patient presented with fixed bullous eruption and severe fever on five separate occasions.
    • These episodes consistently occurred after undergoing intravenous urograms between 1974 and 1979.
    • Diagnosis was challenging due to a significant delay (up to 72 hours) between contrast administration and the onset of symptoms.

    Findings:

    • The patient's condition represents a rare instance of ioderma.
    • The fixed bullous eruption and associated fever were directly linked to urographic contrast media exposure.

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  • This is only the second documented case of true ioderma attributed to these specific contrast agents.
  • Implications:

    • This case underscores the importance of considering delayed hypersensitivity reactions to iodinated contrast media.
    • Clinicians should be aware of the potential for severe dermatological adverse events following urography.
    • Further investigation into the mechanisms and risk factors for contrast-induced ioderma may be warranted.