Renin release and renal pelvic pressure in the isolated perfused dog kidney

The perfused dog kidney was used for a study of the relationship between renin secretion and renal pelvic pressure. The kidney was completely isolated and perfused with perfluorochemical emulsion. During the elevation of renal pelvic pressure, renin secretion rate increased from 0.93 +/- 0.43 to 5.54 +/- 1.57 ng/g min, perfusion flow rate decreased temporarily and recovered within a few minutes.