Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic markers in human bone marrow transplantation

K G Blume, E Beutler, K J Bross

    American Journal of Human Genetics
    |May 1, 1980
    PubMed
    Summary

    Genetic markers like blood cell isozymes and red cell antigens effectively monitor bone marrow engraftment and graft quality after transplantation for acute leukemia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    1342C mutation in Gaucher's disease.

    Lancet (London, England)·1995
    Same author

    Triosephosphate isomerase deficiency: repetitive occurrence of point mutation in amino acid 104 in multiple apparently unrelated families.

    American journal of hematology·1995
    Same author

    Gaucher disease.

    Medicine·1995
    Same author

    Treatment regimens in Gaucher's disease.

    Lancet (London, England)·1995
    Same author

    Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia.

    The Journal of clinical investigation·1995
    Same author

    Erythrocyte fragility and chronic intermittent pigmenturia in a dog.

    Journal of the American Veterinary Medical Association·1995

    Area of Science:

    • Hematology
    • Immunogenetics
    • Oncology

    Background:

    • Bone marrow transplantation is a critical treatment for acute leukemia.
    • Assessing the success of bone marrow engraftment and graft quality is essential for patient outcomes.

    Purpose of the Study:

    • To evaluate the utility of various genetic markers for monitoring bone marrow engraftment.
    • To assess the quality of bone marrow grafts in patients with acute leukemia.

    Main Methods:

    • Analysis of blood cell isozymes.
    • Typing of red cell antigens.
    • Assessment of immunoglobulin allotypes.
    • Examination of marker chromosomes.

    Main Results:

    • These genetic markers provide reliable data for monitoring bone marrow engraftment.
    • The study presents data from 26 patients undergoing bone marrow transplantation for acute leukemia.

    Conclusions:

    • Blood cell isozymes, red cell antigens, immunoglobulin allotypes, and marker chromosomes are valuable tools for monitoring bone marrow engraftment and graft quality in leukemia patients.

    Related Experiment Videos