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Gastric bicarbonate secretion: an update

G L Kauffman

    Brain Research Bulletin
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Gastric mucosa secretes bicarbonate-rich fluid, an active process crucial for protecting the stomach lining. This secretion is stimulated by various agents but inhibited by others, highlighting its regulatory mechanisms.

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    Area of Science:

    • Gastroenterology
    • Physiology
    • Cell Biology

    Background:

    • Gastric fundic and antral mucosa secrete bicarbonate (HCO3-)-rich fluid.
    • Bicarbonate secretion is an active, energy-dependent process occurring at the surface epithelial cell.

    Purpose of the Study:

    • To investigate the mechanisms and regulation of gastric bicarbonate secretion.
    • To explore the role of bicarbonate secretion in gastric mucosal protection.

    Main Methods:

    • In vitro and in vivo studies.
    • Transmembrane HCO3- transport measurements.
    • Isotopic flux (H14CO3), pH stat titration, and pCO2 measurements.

    Main Results:

    • Bicarbonate secretion is stimulated by cholinergic agents, dibutyryl-cGMP, calcium, and prostaglandin E2.

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  • Atropine inhibited stimulated secretion, while acetazolamide, O2 deprivation, noradrenalin, aspirin, and indomethacin inhibited basal secretion.
  • HCO3- secretion, though lower in volume than acid output, has significant neutralizing capacity at the apical membrane.

    • Conclusions:

    • Gastric bicarbonate secretion is a regulated, active process.
    • HCO3- secretion plays a protective role for the gastric mucosal epithelium.
    • The neutralizing capacity of gastric bicarbonate is significant for surface cell protection.