Population studies in Cameroon: hemoglobin S, glucose-6-phosphate dehydrogenase deficiency and falciparum malaria

Examination of blood samples from 1,183 individuals from Cameroon indicates that sickle cell trait frequencies and G6PD deficiency frequencies were heterogeneous among villages as well as within geographic areas and ethnic groups. Mean parasite counts were significantly correlated with Hb AS frequencies for children 6 years of age and under, although no correlation was found for mean parasite counts and G6PD deficiency frequencies. The mean age of sickle cell trait individuals was found to be significantly greater than the mean age of Hb AA individuals. The mean age of G6PD-deficient males did not differ from the mean age of G6PD-normal males. Hb AA and Hb AS children did not differ significantly in mean positive parasite counts. Falciparum malaria appears to be a selective pressure keeping Hb S frequencies high; yet it may not be the major selective force maintaining the G6PD polymorphism.