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Hepatic blood flow: morphologic aspects and physiologic regulation

A M Rappaport

    International Review of Physiology
    |January 1, 1980
    PubMed
    Summary
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    The liver

    Area of Science:

    • Hepatic circulation and microcirculation
    • Vascular morphology and physiology
    • Liver acinar unit organization

    Background:

    • The liver's intricate vascular network is formed by the confluence of portal and arterial streams.
    • Microscopic vessels form the scaffold for parenchymal cell masses within the liver.
    • Understanding hepatic microcirculation is key to liver function.

    Purpose of the Study:

    • To elucidate the relationship between hepatic vascular morphology and blood flow dynamics.
    • To investigate the functional significance of microcirculatory zones within the liver acinus.
    • To analyze the interplay between arterial and portal flow and their impact on liver metabolism and bile production.

    Main Methods:

    • Morphological analysis of hepatic vascular architecture.

    Related Experiment Videos

  • Review of hepatic blood flow measurement techniques and their challenges.
  • Analysis of the roles of arterial and portal blood supply in liver function.

    • Main Results:

    • A PO2 gradient exists within hepatic vessels and tissues, defining three microcirculatory zones with distinct metabolic activities.
    • Hepatic microcirculation is organized into functional units, the vascular core of liver acini.
    • A reciprocal relationship exists between arterial and portal flow, regulated by arteriolar tone.

    Conclusions:

    • Hepatic vascular morphology visually represents dynamic blood flow, enabling the study of circulatory physiology.
    • The identified microcirculatory zones and their metabolic activities are influenced by shifts in arterial flow.
    • Further research is needed to fully clarify the relationship between hepatic blood flow and metabolism.