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[Arnica allergy]

B M Hausen

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |January 1, 1980
    PubMed
    Summary

    Arnica montana, a common medicinal plant, can cause allergic contact dermatitis due to its sensitizing properties. Research confirms its high potential for skin reactions, necessitating re-evaluation for standard testing.

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    Contact dermatitis·2004

    Area of Science:

    • Dermatology
    • Pharmacology
    • Phytochemistry

    Background:

    • Arnica montana L. (Compositae) is a widely used medicinal plant with documented healing properties.
    • Despite its therapeutic benefits, Arnica is also known to possess sensitizing properties, leading to adverse skin reactions.

    Observation:

    • Over 35 references and 100 cases of contact dermatitis linked to Arnica use have been reported in the literature.
    • Four additional cases of contact dermatitis were observed, primarily resulting from self-treatment with Arnica tincture.
    • Occupational contact dermatitis among pharmacists and drug sellers handling Arnica is notably rare.

    Findings:

    • Chemical and animal studies confirm the significant sensitizing capacity of Arnica montana and related species.
    • A low toxic threshold for Arnica often results in primary irritant skin reactions.
    • Sesquiterpene lactones, including helenalin and its derivatives, are identified as the primary sensitizers responsible for allergic reactions.

    Implications:

    • The increasing prevalence of Arnica-containing products in the market warrants attention.
    • It is recommended to reconsider the inclusion of Arnica in standard dermatological testing protocols.
    • Healthcare professionals should be aware of Arnica's sensitizing potential to better advise patients and manage adverse reactions.

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