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Related Experiment Videos

Reference values for blood findings in relatively fit elderly persons

J A Jernigan, J C Gudat, J L Blake

    Journal of the American Geriatrics Society
    |July 1, 1980
    PubMed
    Summary

    Many elderly individuals exhibit numerous "abnormal" blood test results that may be normal for aging. Expanded reference ranges and longitudinal studies are suggested for accurate clinical interpretation in older adults.

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    Area of Science:

    • Gerontology
    • Clinical Pathology
    • Biochemistry

    Background:

    • Aging is associated with patho-anatomic changes that can affect blood values.
    • Establishing normal reference ranges for elderly populations is complex.
    • Cross-sectional studies provide a snapshot but may not capture dynamic physiological changes.

    Purpose of the Study:

    • To investigate the prevalence of abnormal blood test findings in a cohort of fit elderly individuals.
    • To assess the clinical significance of these deviations from standard reference ranges.
    • To evaluate the need for revised reference values in geriatric populations.

    Main Methods:

    • A cross-sectional study involving 73 relatively fit elderly white individuals.
    • Analysis of 53 different blood tests across five categories: hematology, chemistry, thyroid function, protein electrophoresis, and immunology.

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  • Clinical re-evaluation of subjects over a six-month follow-up period.

    • Main Results:

    • Fifteen percent of all blood findings fell outside standard laboratory normal ranges.
    • Most subjects displayed 5 to 10 "abnormal" values across the tested categories.
    • Abnormalities were largely subclinical, requiring only minor adjustments in patient management.

    Conclusions:

    • Current "normal" blood test reference ranges may be too narrow for the elderly population.
    • Longitudinal studies are essential for a more accurate understanding of age-related blood value changes.
    • Findings suggest a need to reconsider standard laboratory reference values in geriatric care.