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Related Experiment Videos

The cloverleaf skull

O Yujnovsky, W L Nyhan

    Clinical Genetics
    |September 1, 1978
    PubMed
    Summary

    Kleeblattschädel abnormality, a rare cloverleaf skull malformation, presents with a trilobed skull and synostosis. This case highlights the severe presentation of this congenital condition in an infant.

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    Area of Science:

    • Medical Genetics
    • Pediatric Radiology
    • Developmental Biology

    Background:

    • Kleeblattschädel abnormality is a rare craniosynostosis syndrome characterized by a distinctive trilobed skull shape.
    • It is often associated with other congenital anomalies, though the specific presentation can vary.
    • Understanding the genetic and developmental underpinnings is crucial for diagnosis and management.

    Observation:

    • The patient exhibited a classic trilobed skull, consistent with Kleeblattschädel abnormality.
    • Radiographic examination revealed synostosis (premature fusion of skull sutures) and a honeycomb appearance of the skull.
    • No extracranial skeletal anomalies were noted in this particular case.

    Findings:

    • The roentgenographic findings confirmed the diagnosis of Kleeblattschädel abnormality.
    • The absence of extracranial anomalies differentiates this case from some other syndromic presentations.
    • The infant's outcome was unfortunately poor, with death at one month of age.

    Implications:

    • This case underscores the severity and potential lethality of untreated Kleeblattschädel abnormality.
    • Further research into the genetic etiology and molecular mechanisms of Kleeblattschädel abnormality is warranted.
    • Improved diagnostic tools and early intervention strategies may offer better outcomes for affected infants.

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