Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor hypercalcemia and "ectopic hyperparathyroidism"

P Skrabanek, J McPartlin, D Powell

    Medicine
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Continuous heart rate variability monitoring, stress and recovery in doctors: a systematic review and meta-analysis.

    Occupational medicine (Oxford, England)·2025
    Same author

    Transcriptome analysis of avian livers reveals different molecular changes to three urban pollutants: Soot, artificial light at night and noise.

    Environmental pollution (Barking, Essex : 1987)·2024
    Same author

    UK funding agency launches digital health hubs: a new catalyst for change?

    NPJ digital medicine·2024
    Same author

    Evaluating the genetic consequences of population subdivision as it unfolds and how to best mitigate them: A rare story about koalas.

    Molecular ecology·2023
    Same author

    A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.

    Journal of intellectual disability research : JIDR·2020
    Same author

    Publisher Correction: A dynamically cold disk galaxy in the early Universe.

    Nature·2020
    Same journal

    A meta-analysis of the effects of Baduanjin training on the human body temperature based on infrared thermography technology.

    Medicine·2026
    Same journal

    The predictive ability of "TyG_CVAI" for incident stroke in individuals with different glycemic metabolic status: A national cohort study.

    Medicine·2026
    Same journal

    Symptoms and quality of life in gynecological cancer patients after surgery: Application of latent profile and network analysis.

    Medicine·2026
    Same journal

    Massive hemoptysis as the initial presentation of Behçet disease complicated by multisite thromboembolism: A case report.

    Medicine·2026
    Same journal

    Dextromethorphan-bupropion-associated pharmacovigilance signals based on the FAERS database: An observational study.

    Medicine·2026
    Same journal

    Effects of Mulligan sustained natural apophyseal glide mobilizations on pain, mobility, and lumbar-related disability in chronic non-specific low back pain: A systematic review and meta-analysis.

    Medicine·2026
    See all related articles

    This study reviewed 307 cases of tumor hypercalcemia, finding multiple causes and mechanisms. While ectopic parathyroid hormone (PTH) production by tumors is not definitively proven, specific tumor types show strong associations with humoral hypercalcemia.

    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Tumor hypercalcemia is a complex clinical issue.
    • Ectopic hyperparathyroidism has been proposed as a cause.
    • The role of parathyroid hormone (PTH) in tumor-associated hypercalcemia requires clarification.

    Purpose of the Study:

    • To collate evidence for and against ectopic hyperparathyroidism.
    • To analyze the association between tumor histology and humoral hypercalcemia.
    • To evaluate the evidence for ectopic PTH production by tumors.

    Main Methods:

    • Systematic review of 307 case reports of tumor hypercalcemia.
    • Analysis of histological patterns of associated tumors.
    • Review of radioimmunoassay and bioassay data for hypercalcemic factors.

    Related Experiment Videos

    Main Results:

    • Humoral hypercalcemia in tumor patients often resolves after tumor removal.
    • Specific tumor histologies (e.g., clear-cell carcinoma, pheochromocytoma) are strongly associated with hypercalcemia.
    • Evidence for ectopic production of biologically active PTH by tumors is inconclusive, with conflicting data and assay limitations.

    Conclusions:

    • The causes and mechanisms of tumor hypercalcemia are likely multifactorial.
    • Specific tumor types exhibit a strong correlation with humoral hypercalcemia, challenging random derepression hypotheses.
    • Further research using sensitive bioassays is needed to identify hypercalcemic factors and understand bone changes in tumor hypercalcemia.