[Chemotherapy of metastasizing colonic carcinomas with nitrosourea compounts. Retrospective analysis]

35 patients with advanced, and previously untreated, colorectal cancer underwent therapy with a combination of 5-fluorouracil, vincristine, DTIC, or one of the nitrosoureas, BCNU or methyl-CCNU, respectively. No complete remission was achieved. 33% of all cases resulted in partial remission and lasted for approximately 3--4 months. Complications were perilous such as neutro- and thrombocytopenia. The overal quality of life was poor. Though several parameters influence these results, we think that the above-listed nitrosoureas do not add substance to the chemotherapy of colorectal cancer.