[Malignant melanoma: spontaneous course, therapy and prognosis]

The natural history, treatment and prognosis of malignant melanoma are reviewed. Stage, histologic level of invasion and clinical type are the most important prognostic factors. Surgical approach for treatment of the primary tumor, adjuvant therapy and treatment of advanced disease (chemotherapy, hormonal manipulation and immunotherapy) are discussed. 5-year survival rates are tabulated in relation to the most important prognostic factors.