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International transoceanic kidney sharing

R E McCabe, A Curtis, M Jean-Jacques

    Transplantation
    |July 1, 1980
    PubMed
    Summary
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    International kidney sharing significantly improves organ utilization and transplant success rates for patients with preformed antibodies. This collaboration overcomes donor shortages and enhances access to life-saving kidney transplants.

    Area of Science:

    • Nephrology
    • Transplantation immunology
    • Organ donation

    Background:

    • Cadaver kidney shortages are a major challenge in the United States, limiting transplantation options.
    • Preformed antibodies in recipients complicate donor-recipient matching, even with computerized sharing systems.
    • Inefficient organ utilization exacerbates the scarcity of transplantable kidneys.

    Purpose of the Study:

    • To evaluate the effectiveness of international organ sharing in addressing kidney shortages.
    • To improve the utilization of cadaver kidneys for transplantation.
    • To facilitate transplants for highly sensitized patients with preformed antibodies.

    Main Methods:

    • A collaborative international kidney sharing program was established involving Italy, the Soviet Union, West Germany, and the USA.

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  • Eleven cadaver kidneys were shared between these countries.
  • Transplant outcomes were monitored for all shared kidneys.

    • Main Results:

    • Ten out of eleven shared kidneys (91%) resulted in successful transplants.
    • International sharing led to better bilateral utilization of donated kidneys.
    • The program increased the availability of kidneys for cytotoxic patients.

    Conclusions:

    • International organ sharing is a viable strategy to overcome national kidney shortages.
    • Collaborative efforts enhance organ utilization and improve transplant outcomes, particularly for antibody-positive recipients.
    • Expanding international cooperation can significantly increase access to kidney transplantation globally.