Comparison of propranolol and inderal L.A. in patients with angina

TWELVE patients with moderately severe angina pectoris completed a double blind cross-over comparison of conventional propranolol (40 mg q.i.d.) and Inderal L.A. (160 mg once daily) with regard to therapeutic effectiveness, blood levels, compliance and patient acceptability.Exercise tolerance was assessed using standardised treadmill testing at 1, 2, 4, 8, 12 and 24 hours after the morning dose. The double placebo technique was used.Patient compliance was excellent for both regimes and no serious side effects were reported. No significant differences in exercise tolerance or blood levels were observed between the two treatments at any time.