Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial cell density in donor corneas

S Sperling

    Acta Ophthalmologica
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Donor cornea endothelial cell density is similar between paired eyes, with age affecting younger donors. This finding aids corneal transplantation research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Borderline T-SPOT.TB results: test reliability, patient characteristics, and TB progression.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
    Same author

    [Beyond antibiotic therapy - Future antiinfective strategies - Update 2017].

    Der Unfallchirurg·2017
    Same author

    Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.

    Molecular psychiatry·2016
    Same author

    Positive and negative bioimprinted polymeric substrates: new platforms for cell culture.

    Biofabrication·2015
    Same author

    Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

    Molecular psychiatry·2013
    Same author

    A single gene defect causing claustrophobia.

    Translational psychiatry·2013
    Same journal

    En face localization of retinal telangiectatic capillaries using OCT compared with ICG angiography in chronic vascular macular oedema.

    Acta ophthalmologica·2026
    Same journal

    Usher syndrome-related visual impairment in Finland: A 35-year nationwide register-based study (1985-2019).

    Acta ophthalmologica·2026
    Same journal

    Three years of ocular proton therapy in the Netherlands, clinical results.

    Acta ophthalmologica·2026
    Same journal

    Risk factors for acquisition and severity of Acanthamoeba and Fusarium keratitis in contact lens users-A case-control and clinical-epidemiological study, 2009-2020.

    Acta ophthalmologica·2026
    Same journal

    Distinguish polypoidal choroidal vasculopathy through choroidal alterations: A systematic review, meta-analysis and narrative synthesis.

    Acta ophthalmologica·2026
    Same journal

    Ocular blood flow and retinal oxygen saturation measurements in central retinal artery occlusion.

    Acta ophthalmologica·2026
    See all related articles

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Corneal Science

    Background:

    • Endothelial cell density is a critical factor in corneal health and transplantation success.
    • Age-related changes in corneal endothelial cells are well-documented, but paired eye correlations require further investigation.

    Purpose of the Study:

    • To investigate the correlation of endothelial cell density between paired donor corneas.
    • To determine the influence of donor age on endothelial cell density and its correlation in paired corneas.

    Main Methods:

    • Visualizing endothelial cells by inducing cell border swelling in isotonic saline.
    • Analyzing 68 pairs of donor corneas.
    • Correlating numerical cell density with donor age and between paired corneas.

    Related Experiment Videos

    Main Results:

    • A significant correlation was found between endothelial cell densities in paired corneas (within +/- 10.97% of each other).
    • Age negatively correlated with cell density in donors younger than 50 years.
    • This age-related correlation was not observed in older donors.
    • Correction for age, sex, or mean cell density did not significantly improve the precision of the paired cornea estimate.

    Conclusions:

    • Paired donor corneas exhibit highly similar endothelial cell densities, suggesting inherent bilateral consistency.
    • Donor age is a significant factor influencing endothelial cell density, particularly in younger individuals.
    • These findings have implications for donor eye selection and predicting outcomes in corneal transplantation.