Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation of minoxidil

D D Miller, D W Love

    American Journal of Hospital Pharmacy
    |June 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Minoxidil is a potent vasodilator for severe hypertension, but its use requires a diuretic and beta blocker due to side effects like reflex tachycardia and fluid retention. It

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Novel Antimitotic Agent SP-1-39 Inhibits Head and Neck Squamous Cell Carcinoma.

    Journal of dental research·2024
    Same author

    Mycobacterium immunogenum folliculitis on the lower extremities of a healthy young adult.

    Clinical and experimental dermatology·2018
    Same author

    Journal of Nuclear Cardiology Nuclear Cardiology News Update.

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2016
    Same author

    Agriculture. Research principles for developing country food value chains.

    Science (New York, N.Y.)·2011
    Same author

    Action of nifedipine in ischemic heart disease.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Microwave-assisted synthesis of medicinally relevant indoles.

    Current medicinal chemistry·2010
    Same journal

    National health care reform, Part 2: Response to pharmacists.

    American journal of hospital pharmacy·1994
    Same journal

    Validity of originality assessment.

    American journal of hospital pharmacy·1994
    Same journal

    Unit dose dispensing of chromic phosphate P 32 suspension.

    American journal of hospital pharmacy·1994
    Same journal

    Hydralazine injection still available.

    American journal of hospital pharmacy·1994
    Same journal

    Improved extemporaneous formulation of cyclosporine ophthalmic drops.

    American journal of hospital pharmacy·1994
    Same journal

    Paclitaxel diluent and the case of the slippery spike.

    American journal of hospital pharmacy·1994
    See all related articles

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Clinical Therapeutics

    Background:

    • Minoxidil is a recently approved antihypertensive agent.
    • It functions as an orally effective vasodilator.
    • Its mechanism involves selective relaxation of peripheral arteriolar smooth muscle.

    Purpose of the Study:

    • To review the chemistry, pharmacokinetics, mechanism of action, clinical studies, adverse effects, toxicology, indications, contraindications, drug interactions, and dosing of minoxidil.
    • To assess its efficacy and safety in managing severe hypertension.

    Main Methods:

    • Review of existing literature on minoxidil.
    • Analysis of controlled and uncontrolled clinical studies.
    • Evaluation of pharmacokinetic and pharmacodynamic properties.

    Related Experiment Videos

    Main Results:

    • Minoxidil effectively lowers blood pressure in severe hypertension, including cases secondary to renal or renovascular disease and essential hypertension.
    • Common adverse effects include reflex tachycardia, renin stimulation, and sodium retention, necessitating co-administration with a diuretic and a sympathoplegic agent (e.g., beta blocker).
    • Other adverse effects include hirsutism and pericardial effusions.

    Conclusions:

    • Minoxidil is a potent antihypertensive agent effective in treatment-resistant severe hypertension.
    • Its significant adverse effects limit its use to patients intolerant or unresponsive to other antihypertensive drugs.
    • Concomitant use of diuretics and beta blockers is essential for managing minoxidil's side effects.