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Gentamicin-resistant Serratia marcescens endophthalmitis
Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 1, 1980
Summary
Serratia marcescens caused metastatic endophthalmitis and showed resistance to common antibiotics. Amikacin sulfate proved effective, highlighting its importance in treating resistant Gram-negative infections.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Metastatic endophthalmitis is a severe intraocular infection that can arise from bloodstream seeding.
- Serratia marcescens is an opportunistic Gram-negative bacterium known for its potential to cause serious infections.
Observation:
- A case of metastatic endophthalmitis was identified, originating from a Gram-negative bacterium.
- The causative agent, Serratia marcescens, demonstrated resistance to gentamicin sulfate and tobramycin.
Findings:
- The bacterial isolate was uniquely sensitive to amikacin sulfate, a recently approved semisynthetic aminoglycoside.
- This sensitivity suggests amikacin sulfate as a viable therapeutic option for specific resistant strains.
Implications:
- The study underscores the growing challenge of antibiotic resistance in ocular pathogens.
- Amikacin sulfate represents a crucial treatment alternative for endophthalmitis caused by antibiotic-resistant Serratia marcescens.
- Increased awareness of Serratia marcescens as a systemic and ocular pathogen is warranted.