Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercalcaemia in malignancy

R S Bockman

    Clinics in Endocrinology and Metabolism
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Cancer hypercalcaemia pathogenesis remains complex, involving various mediators and pathways influenced by tumor biology. Research aims to identify these specific agents and pathways for targeted therapies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk factors for multi-joint disease in patients with glucocorticoid-induced osteonecrosis.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    Low volumetric bone density is a risk factor for early complications after spine fusion surgery.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
    Same author

    Vitamin D and bisphosphonate response.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014
    Same author

    The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2012
    Same author

    Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response.

    Cell stress & chaperones·2001
    Same author

    Bone strength and related traits in HcB/Dem recombinant congenic mice.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2001
    Same journal

    Long-term complications of diabetes.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic retinopathy: current concepts of evaluation and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic neuropathies and pain.

    Clinics in endocrinology and metabolism·1986
    Same journal

    The diabetic foot: pathophysiology and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Autonomic neuropathy: its diagnosis and prognosis.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Dialysis: continuous ambulatory peritoneal dialysis and haemodialysis.

    Clinics in endocrinology and metabolism·1986
    See all related articles

    Area of Science:

    • Oncology
    • Endocrinology
    • Pathophysiology

    Background:

    • Cancer-associated hypercalcaemia is a complex clinical challenge.
    • Multiple humoral and cellular mediators contribute to its development.
    • Pathways leading to hypercalcaemia are tumor-specific, affecting osteolysis.

    Purpose of the Study:

    • To elucidate the enigmatic pathogenesis of cancer hypercalcaemia.
    • To identify the diverse mediators and pathophysiological pathways involved.
    • To explore potential targeted therapies for cancer hypercalcaemia.

    Main Methods:

    • Review of current literature on cancer hypercalcaemia.
    • Analysis of humoral and cellular mediators.
    • Investigation of tumor-specific pathophysiological pathways.

    Related Experiment Videos

    Main Results:

    • Pathogenesis involves various mediators from tumor or normal tissues.
    • Osteolysis and hypercalcaemia mechanisms differ based on tumor type (e.g., breast vs. lung cancer).
    • Consequences of hypercalcaemia are severe and require immediate management.

    Conclusions:

    • Understanding tumor-specific mechanisms is crucial for managing cancer hypercalcaemia.
    • Ongoing research promises identification of causative agents and pathways.
    • Future therapies may target specific pathophysiological processes to arrest hypercalcaemia.