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Arginine does not influence insulin binding on circulating monocytes

R De Pirro, G Tamburrano, A Fusco

    Endokrinologie
    |March 1, 1980
    PubMed
    Summary
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    Pancreatic glucagon does not influence insulin receptor affinity or concentration in humans. Studies show glucose, food, or exercise alter insulin binding, but glucagon

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    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Acute physiological changes like glucose ingestion, food intake, or exercise rapidly alter monocyte insulin binding.
    • Pancreatic glucagon's role in these insulin receptor variations is suspected, as it often rises with increased insulin receptor affinity.
    • Insulin itself appears to play a minimal role in modulating insulin receptor binding during these events.

    Purpose of the Study:

    • To investigate the specific role of pancreatic glucagon in modulating monocyte insulin receptor affinity and concentration.
    • To determine if elevated pancreatic glucagon levels, independent of direct insulin effects, impact insulin receptor dynamics.

    Main Methods:

    • Studied the effect of arginine infusion on monocyte insulin receptor characteristics in five healthy human subjects.
    • Arginine infusion was used to stimulate both insulin and pancreatic glucagon release simultaneously.
    • Monocyte insulin receptor affinity and concentration were measured before and after arginine infusion.

    Main Results:

    • Arginine infusion did not induce any significant changes in monocyte insulin receptor affinity.
    • No alterations in monocyte insulin receptor concentration were observed following arginine infusion.
    • These findings suggest that simultaneous increases in plasma insulin and pancreatic glucagon do not affect insulin receptor parameters.

    Conclusions:

    • Pancreatic glucagon does not appear to be a primary mediator of changes in monocyte insulin receptor affinity or concentration.
    • The observed variations in insulin binding during glucose ingestion, food intake, or exercise are likely regulated by factors other than pancreatic glucagon.
    • Further research is needed to elucidate the precise mechanisms governing insulin receptor modulation in response to metabolic stimuli.